A systematic review conducted by Sachdeva et al. found 38 articles regarding patients diagnosed with SJS/TEN and treated with biologics.41 Apart from finding that anti-TNF-α therapy, specifically etanercept, showed improved outcomes as monotherapy, they also remarked that biologic monotherapy may be safer than combination therapy with corticosteroids, IVIG or ciclosporin. The gene discussed is TNF; the disease is toxic epidermal necrolysis.