CD4 and neoplasm: Finally, Evobodies induce potent tumor cell elimination and Vγ9Vδ2 T cell proliferation at very low E:T rations in ex vivo freshly isolated patient tumors with endogenous TILs and avoid immune exhaustion by circumventing the activation of CD4 Tregs or upregulation of T cell immunoreceptor with Ig and ITIM domains (TIGIT).