CD4 and neoplasm: The subsequent reaction is highly potent and comprises a versatile and complex response — including pro-inflammatory cytokine release (47), antigen cross-presentation of pathogenic and tumor-antigens (48), cross-activation of other immune cells including CD4 and CD8 T cells (28), massive expansion of Vγ9Vδ2 T cells (49), and ultimately, elimination of the infected BTN3A - activated target cell (24).