For example, cytokines in the SASP, such as interleukin-6 (IL-6), interleukin-8 (IL-8), and matrix metalloproteinases (MMPs), can induce angiogenesis, EMT, and immune suppression, creating favorable conditions for tumor cell invasion and metastasis (14).Recent studies have shown a close relationship between CAFs and cellular senescence. Here, IL6 is linked to neoplasm.