CXCL8 and familial pancreatic carcinoma: This finding emphasizes the critical role of IL-8 in mediating the interaction between senescent CAFs and tumor cells, providing a mechanism for the increased metastatic potential of DGC (62).Similarly, studies have also shown that IL-8 plays a role in senescent CAFs, with researchers identifying that senescent CAFs in pancreatic cancer promote tumor cell invasion through IL-8 secretion, exhibiting distinct pro-cancer activity (63).