Considering that these monocytes highly express SPP1 (Supplementary Figure S5e) and SPP1+ Macrophages were reported to express immunoglobulin-related genes and monocyte marker VCAN, these cells might be a subset of SPP1+ Macrophages, a kind of tumor-promoting macrophage associated with unfavorable prognosis of patients (22). Here, VCAN is linked to neoplasm.