Other evidences show that the myCAF promote HCC progression via the COL-IDDR1 pathway, involving molecules such as COL1A1, COL1A2, COL5A1, COL6A3, POSTN, DCN, FAP, SPP1, MMP14, MMP11 and TIMP1 (16, 36, 37). This evidence concerns the gene FAP and hepatocellular carcinoma.