further explained that CAFs linked with HCC induce programmed death-ligand 1-positive (PD-L1+) neutrophils via the interleukin-6-signal transducer and activator of transcription 3 (IL-6/STAT3) signaling pathway, thereby augmenting immune evasion by hindering T-cell functionality (65). The gene discussed is CD274; the disease is hepatocellular carcinoma.