CAFs promote VM in HCC via TGF-β/SDF1-induced VE-cadherin/MMP2/LAMC2 axis, while miR-101 can suppress VM by dual targeting TGF-βR1/Smad2 in HCC cells and SDF1 in CAFs for anti-metastasis therapy (48). The gene discussed is TGFBR1; the disease is hepatocellular carcinoma.