These phenotypic and functional improvements correlate with LTN-mediated transcriptional upregulation of memory-associated factors Tcf7 (encoding TCF1) and Foxo1. In vivo, the combination of LTN and CAR-T significantly enhances tumor control in syngeneic murine models of colon carcinoma and melanoma. The gene discussed is FOXO1; the disease is colon carcinoma.