CXCL8 and chronic recurrent multifocal osteomyelitis: Autoinflammatory phenotypes include chronic recurrent multifocal osteomyelitis (CRMO), juvenile idiopathic arthritis, and intestinal inflammation, which may result from enhanced monocyte responses to TLR ligands and increased secretion of proinflammatory factors (e.g., IL-8, IL-18) (122, 123).