HES1 and uveal melanoma: In uveal melanoma, lncRNA PAUPAR downregulates Hes1 expression by inhibiting histone H3K4 methylation, thereby suppressing tumorigenesis and metastasis (132); in glioblastoma, there is a feedback regulation between Smarcd1, a component of the chromatin remodeling complex SWI/SNF, and the Notch1/Hes1 axis, where Smarcd1 overexpression reduces Notch1 expression, and Notch1 knockdown conversely increases Smarcd1 expression by inhibiting Hes1, ultimately inhibiting the malignant phenotype of the tumor (133).