In colorectal cancer, the STRAP protein competitively inhibits the assembly of the histone methyltransferase PRC2 complex (containing EZH2 and SUZ12), reducing the enrichment of H3K27me3 at the promoter regions of NOTCH pathway-related genes, including Hes1, thereby activating Hes1 expression and promoting CSC self-renewal and tumorigenesis (126). Here, HES1 is linked to colorectal cancer.