In uveal melanoma, lncRNA PAUPAR downregulates Hes1 expression by inhibiting histone H3K4 methylation, thereby suppressing tumorigenesis and metastasis (132); in glioblastoma, there is a feedback regulation between Smarcd1, a component of the chromatin remodeling complex SWI/SNF, and the Notch1/Hes1 axis, where Smarcd1 overexpression reduces Notch1 expression, and Notch1 knockdown conversely increases Smarcd1 expression by inhibiting Hes1, ultimately inhibiting the malignant phenotype of the tumor (133). Here, HES1 is linked to neoplasm.