For example, targeting Notch1-Hes1 signaling inhibits proliferation in cervical cancer (91), ovarian cancer (92), and glioma (93); induces apoptosis in cervical carcinoma (70), attenuates migration/invasion in non-small cell lung cancer (NSCLC) and colon cancer models (94, 95); and enhances radiosensitivity in colorectal cancer (84). The gene discussed is NOTCH1; the disease is central nervous system cancer.