Previous studies have observed that LIMS2 silencing significantly enhances the migratory ability of gastric cancer cells (50), In this study, by integrating transcriptomic data with Mendelian randomization (MR) analysis, we found that LIMS2 expression was significantly downregulated in bladder cancer tissues, consistent with the expression pattern reported in gastric cancer. The gene discussed is LIMS2; the disease is gastric cancer.