Finally, intersecting these key genes with risk-consistent genes yielded eight immune-related genes that were negatively associated with bladder cancer risk: LIMS2, TP53INP2, IRAK3, STX2, CYP27A1, IL11RA, KCNMB1, and PDLIM7 (Figure 4C). This evidence concerns the gene IRAK3 and urinary bladder cancer.