For example, the CBP/p300 inhibitor CPI-0610 shows promise in preclinical models of pancreatic cancer by disrupting the lactylation-TTK/BUB1B feedback loop, while HDAC1 agonist entinostat reverses immunosuppression in colorectal cancer by de-repressing CD8+ T cell infiltration. The gene discussed is TTK; the disease is pancreatic neoplasm.