For the elevated IgE, Allergy and Immunology were consulted, and they determined that while the patient did have a history of concurrent mild intermittent asthma, it is unlikely to explain the high levels of eosinophilia or IgE, considering that the patient had no active symptoms or exacerbations currently or in the recent past, despite being off medications for a long duration. The gene discussed is IGHE; the disease is asthma.