ENO2 and peripheral neuropathy: For peripheral neuropathy, the significant independent risk factors were diabetes duration with odds ratio of 3.42 per 5-year increase (95% CI: 2.41-4.87, p<0.001), serum NSE levels with odds ratio of 1.92 per 1 ng/mL increase (95% CI: 1.54-2.41, p<0.001), and HbA1c with odds ratio of 1.67 per 1% increase (95% CI: 1.31-2.13, p<0.001).