ENO2 and neuropathy: The landmark study by Li et al. in 2013 involving 568 Chinese subjects reported NSE levels of 10.8±2.8 μg/L in diabetic patients with neuropathy compared to 9.1±1.5 μg/L in those without neuropathy, with an optimal cutoff of 10.10 μg/L achieving 66.3% sensitivity and 72.5% specificity with an AUC of 0.73 [15].