Patients with no neuropathy had mean NSE of 6.80 ± 1.52 ng/mL, mild neuropathy had mean NSE of 7.52 ± 1.83 ng/mL, moderate neuropathy had mean NSE of 8.91 ± 1.42 ng/mL, and severe neuropathy had mean NSE of 9.77 ± 1.49 ng/mL (p<0.001 for all comparisons against no neuropathy). Here, ENO2 is linked to neuropathy.