Patients with peripheral neuropathy had significantly higher serum NSE levels with mean of 9.18 ± 1.43 ng/mL and median of 9.21 ng/mL compared to those without peripheral neuropathy who had mean of 6.83 ± 1.52 ng/mL and median of 6.92 ng/mL, representing approximately 34% elevation (p<0.001). Here, ENO2 is linked to peripheral neuropathy.