CD4 and AIDS: A 50-year-old man with acquired immunodeficiency syndrome (AIDS) because of infection with an extremely drug-resistant human immunodeficiency virus (HIV) strain (>250,000 RNA copies, CD4- and T-cell lymphocytes <1%, <20/mm3) presented with numerous non-pruritic, non-painful, hyperpigmented flat skin lesions of various sizes throughout his body (sparing palms and soles) (Figures 1A, 1B, 1C).