Increased MTs expression has been observed during the acute phases of conditions such as inflammatory bowel disease (IBD), rheumatoid arthritis, atopic dermatitis, Parkinson's disease, and multiple sclerosis, where in some cases, MTs is thought to exert protective or therapeutic effects [3, 16, 23, 24, 59–62]. The gene discussed is TIMM8A; the disease is inflammatory bowel disease.