The majority of CRC cases are due to altered KRAS and B‐Raf, which activate WNT‐APC‐CTNNB1, PI3K, TGFB1‐SMAD, and RAS–RAF–MAPK pathways and promote proliferation with suppressed apoptosis (Ahronian et al. 2015). The gene discussed is CTNNB1; the disease is colorectal carcinoma.