The genes linked with genetic mutations are VHL, BAP‐1, PBRM‐1, SETD2, MTOR, and KDM5C; furthermore, genetic modifications in 5q, 14q, 7q, 8p, and 9p are also responsible for RCC manifestation (Hsieh et al. 2017). The gene discussed is KDM5C; the disease is renal cell carcinoma.