Serine/threonine (PIM‐1) a proto‐oncogene, is vital in cancer development and cell proliferation, and studies have proved that PIM‐1 kinase, involved in cellular development, immunoregulation, and oncogenesis, is an appropriate therapeutic target for PC (Wang, Li, et al. 2017; Wang, Man, et al. 2017). The gene discussed is PIM1; the disease is pachyonychia congenita.