Liao et al. (2020) examined the effectiveness of EGCG‐derived Y6 against HCC and concluded that the EGCG derivative Y6 significantly reduced angiogenesis and tumor progression via modulating the MAPK/ERK1/2 and PI3K/AKT/HIF‐1α/VEGF axis. Here, PIK3CA is linked to hepatocellular carcinoma.