RIPK3 and neoplasm: We suggest a hybrid gene delivery platform integrating adeno‐associated virus (AAV)‐mediated expression of receptor‐interacting kinase 3(RIPK3) with manganese dioxide‐polyethyleneimine (MnO2‐PEI) to induce necroptosis and immunogenic cell death (ICD), thereby remodeling the tumor microenvironment and enhancing antitumor immunity.