OTUD5 and primary biliary cholangitis: Given that global deletion of DUBA is lethal in mice, cell‐specific DUBA knockout mice are used to study the in vivo function of DUBA.[27] Previous studies have found that DUBA affects intestinal inflammation, innate antiviral and antitumor immunity, and kidney inflammation by specifically regulating T cells, macrophages, and podocytes, respectively.[13, 14, 24] In humans, genetic variants of Duba are associated with primary biliary cholangitis,[28] highlighting the significance of DUBA in inflammatory diseases.