In addition, chronic neuroinflammation mediated by the cGAS‐STING pathway contributes to aging‐related neurodegeneration and multiple neurodegenerative diseases, such as amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disease.[29] Given that DUBA potentiates cGAS‐STING activation by stabilizing STING,[24] it is also possible that DUBA promotes neurodegenerative diseases by regulating chronic neuroinflammation. Here, CGAS is linked to juvenile Huntington disease.