The literature regarding serum and tissue NOx [15, 42, 48, 49, 50, 51] and tissue eNOS [15, 42, 51] in T2D is inconsistent and appears to depend on the duration of T2D, where no change in serum NOx has been reported 1 [50], 2 [42, 50] and 3 [51] months after induction of T2D, but decreased serum and tissue NOx and tissue eNOS have been reported after 6 months [15]. The gene discussed is NOS3; the disease is type 2 diabetes mellitus.