Consequently, a novel EV delivery system (siT/MOF@EVs), which targets the tumor cell membrane–cytoplasm–mitochondria cascade, is engineered to codeliver TEAD4‐siRNA (siTEAD4) and a mitochondria‐targeting metal–organic framework (T/MOF) to overcome tumor heterogeneity. This evidence concerns the gene TEAD4 and neoplasm.