TEAD4 and neoplasm: In this study, we prepared a Zn/Mn‐MOF that specifically targets tumor cell mitochondria as the primary carrier, loaded monoatomic Pd‐binding nanozymes into the pores, attached TEAD4‐siRNA (siTEAD4) to the surface via electrostatic adsorption, and then performed decoy EVs encapsulation to construct an EV delivery system that targets the cell membrane‒cytoplasm‒mitochondria cascade.