found that the deacetylation of SIRT1 enhances the tumor suppressor activity of HINT1 by promoting its interaction with β‐catenin or MITF in colon cancer and melanoma cells.[12] Beyond their roles in tumor‐related diseases, the protective effects of HINT family members in cardiovascular diseases have gained increasing attention in recent years. The gene discussed is HINT1; the disease is colonic neoplasm.