found that the administration of acidified malonate during reperfusion enabled low‐dose malonate to provide long‐term cardiac protection after myocardial infarction, thus preventing IRI and heart failure following MI.[20] In our in vitro experiments, knockdown of HINT3 led to an increase in SDH enzymatic activity, whereas overexpression of HINT3 resulted in a decrease in SDH activity. This evidence concerns the gene HINT3 and heart failure.