HINT2 and cardiac hypertrophy: Additionally, in a mouse model of pressure overload‐induced cardiac hypertrophy, we observed that HINT2 alleviates cardiac remodeling by modulating the activity and assembly of mitochondrial complex I.[14] In contrast to HINT1 and HINT2, research on HINT3 is very limited, especially concerning its role in cardiovascular disease – a role that remains virtually unexplored.