This finding is consistent with other studies’ findings.[37] Additionally, the transcription level of CGRP is higher than that of SP in periodontium.[38] In the trigeminal ganglia, CGRP+ neurons are also denser than SP+ neurons.[39] In our study, the bone‐forming capacities in diabetic mice with periodontitis were significantly promoted by the local application of CGRP, without the involvement of other neurotrophins and neuropeptides. Here, NPS is linked to periodontitis.