INS and obesity due to melanocortin 4 receptor deficiency: This kind of type of mouse develops obesity and type 2 hyperinsulinemic diabetes.[31] Notably, there are more functional abnormalities of sensory nerves in type 1 insulinopenic diabetes compared to type 2 diabetes.[32] Specifically, the deficiency of insulin appears to be more important in nociceptive neuropathy than hyperglycemia.