CDKN1A and neoplasm: In normal cells, KLF4 may act as a tumor suppressor by inducing p21CIP1 (CDKN1A), but in cancerous or transformed cells, KLF4 may exert oncogenic functions by antagonizing p53 activity.[42] The complexity of KLF4's function in cancer is further underscored by its structural and functional similarities to other KLF family proteins, which consists of 18 members, each responding to diverse stress signals.[43, 44] This highlights the need for further investigations into context‐dependent KLF4 regulation and its interplay with other oncogenic and tumor‐suppressive pathways.