We previously demonstrated that Nrf2 serves as a master regulator of metabolic reprogramming and cancer stem‐like cell (CSC) generation in the human bronchial epithelial cell line BEAS‐2B exposed to environmentally relevant concentrations of arsenic (As3+).[11, 12] Beyond its well‐established role in antioxidant defense, global chromatin immunoprecipitation with sequencing (ChIP‐seq) analysis identified several Nrf2‐regulated genes essential for shifting metabolism from the mitochondrial citric acid (TCA) cycle to glycolysis and glycolytic shunting pathways. This evidence concerns the gene NFE2L2 and cancer.