Analysis of data from the NCI Genomic Data Commons (GDC) Data Portal revealed that multiple cancer types, particularly lung squamous carcinoma (LUSC) and lung adenocarcinoma (LUAD), frequently exhibited copy number variations (CNV) gains in the Nrf2 gene, which were strongly associated with poorer overall survival (Figure 2B). The gene discussed is NFE2L2; the disease is lung adenocarcinoma.