KLF4 and cancer: Emerging evidence indicates that KLF4 orchestrates the topological reorganization of enhancer‐based TADs and genome‐wide enhancer rewiring,[49] in addition to directly interacting with and recruiting CREBBP.[50] However, in differentiated or cancer cells, KLF4 alone may be insufficient for CREBBP recruitment, enhancer activation, or chromatin architectural reorganization, suggesting the need for additional architectural factors or co‐regulators.