KLF4 and pancreatic neoplasm: One of the earliest findings supporting KLF4's oncogenic role is the attenuation of mutant KrasG12D‐driven pancreatic intraepithelial neoplasia (PanIN) following Klf4 ablation in a mouse model of pancreatic cancer.[37] Stress‐induced KLF4 expression has been implicated in acinar‐to‐ductal metaplasia (ADM), a precursor lesion in PanIN development.