The frequency of alterations differed between TRS and complex sarcomas in TP53 (17.9% vs. 41.7%, p < 0.001), RB1 (2.8% vs. 26.0%, p = 0.0015), and CDKN2A (5.6% vs. 9.0%, p = 0.039) (Tables [Link], [Link], [Link]). Here, RB1 is linked to sarcoma.