ALK and lung adenocarcinoma: <h4>Introduction</h4>This study aimed to explore the relationship between radiomics features and anaplastic lymphoma kinase (ALK) gene mutation status in lung adenocarcinoma and to develop a radiomics nomogram for preoperative prediction of ALK mutations.<h4>Methods</h4>A retrospective analysis was conducted on 210 patients with histologically confirmed lung adenocarcinoma (50 ALK mutation-positive, 160 mutation-negative), divided into training (n=147) and validation (n=63) cohorts (7:3 ratio).