LAG3 and amyotrophic lateral sclerosis: Eight biomarkers exhibited differential specificity: sCD28, and sTIM-3 were higher in ALS patients than in Mimic, while sGITR, sCD137, sIDO, sLAG3, sPD-L2 and sCD80 were preferentially upregulated relative to HC (all p < 0.05, Figure 2E–L).