BAP1 and nonpapillary renal cell carcinoma: Overall, our data indicate the following: 1) BAP1 loss leads to SRC upregulation, and BAP1 regulates SRC levels transcriptionally; 2) SRC binds to and phosphorylates BECN1, thereby inhibiting autophagy; and 3) treatment of BAP1-deficient tumors with SRC inhibitors and autophagy inducers decreases tumor growth and viability in vitro, in ovo and ex vivo in PDTOs of UM and ccRCC.