Reverse-phase protein array (RPPA) on KIRC-TCGA curated data showed that one of the most upregulated proteins in BAP1-mutant tumors from ccRCC patients is the non-receptor tyrosine kinase SRC, and it also showed a significant decrease in the phosphorylation levels of the inhibitory SRC site Y527 (Figure 1A and S1A). This evidence concerns the gene BAP1 and nonpapillary renal cell carcinoma.