Overall, our data indicate the following: 1) BAP1 loss leads to SRC upregulation, and BAP1 regulates SRC levels transcriptionally; 2) SRC binds to and phosphorylates BECN1, thereby inhibiting autophagy; and 3) treatment of BAP1-deficient tumors with SRC inhibitors and autophagy inducers decreases tumor growth and viability in vitro, in ovo and ex vivo in PDTOs of UM and ccRCC. Here, BECN1 is linked to nonpapillary renal cell carcinoma.