In addition, UMRC-6 cells reconstituted with BAP1 mutants found in cancer patients [5] indicate that only the wild-type BAP1 is able to induce autophagy (Figure 2J–L and S2L,M), therefore, suggesting that all clinically relevant BAP1 mutations analyzed behave as loss-of-function in their ability to modulate autophagy. The gene discussed is BAP1; the disease is cancer.