BAP1 and cancer: BAP1 has been found to be mutated in 80% of metastatic uveal melanoma (UM) [6], 63% of malignant pleural mesothelioma [7,8], 25% of intrahepatic cholangiocarcinoma [9], 15% of clear-cell renal cell carcinoma (ccRCC) [10], and at lower frequencies in other cancers.