In colorectal cancer, increased MCU-mediated calcium uptake promotes mitochondrial biogenesis and tumor growth.81 MCU drives pancreatic cancer progression by enhancing mitochondrial Ca2+ uptake and regulating EMT-dependent metastasis.82 Furthermore, MCU regulates branched-chain amino acid catabolism via calcium-dependent PDH activity in fibrolamellar carcinoma.83 Here, MCU is linked to familial pancreatic carcinoma.