Recent studies have indicated that SHMT promotes cancer cell survival in KRAS and liver kinase B1 (LKB1) double-mutated NSCLC by increasing serine-glycine-one-carbon (SGOC) metabolism and antioxidant defense.233 MTHFD1 maintains the nucleotide balance in cancer cells by regulating folate metabolism and pyrimidine synthesis. This evidence concerns the gene MTHFD1 and cancer.