PIK3CA and cancer: Cancer cells exhibit distinctive metabolic reprogramming, a cellular adaptation that rapidly rewires metabolic networks to support uncontrolled cell growth and survival, exemplified by the Warburg effect, which accelerates ATP generation and biosynthesis.6 This metabolic transformation is typically driven by oncogenic pathways, including the PI3K/Akt/mTOR and c-Myc pathways.7 Despite enhanced glycolysis, functional mitochondria remain crucial through multiple mechanisms.