SDHB and neoplasm: In gliomas, HIF can promote tumor progression by regulating c-Myc transcriptional activity.243 Mutations in TCA cycle enzymes such as SDH can lead to metabolite accumulation (such as succinate), inhibiting prolyl hydroxylases and affecting HIF-1α stability.244 These mechanisms collectively promote a shift in cellular metabolism toward glycolysis, reducing the dependence on OXPHOS and conferring survival advantages under hypoxic conditions.