RIPK3 and cancer: Studies have shown that mitoROS generation promotes RIPK3-mediated necroptosis via the ROS/JNK/Bax pathway.137 An imbalance in mitochondrial dynamics plays crucial roles in necroptosis, such as DRP1-mediated mitochondrial fission, which promotes hepatocyte necroptosis.143 Additionally, a recent study revealed that NR4A1 depletion inhibits colorectal cancer progression by promoting RIPK3-dependent necroptosis via the RIG-I-like receptor pathway, further highlighting the importance of modulating necroptosis for cancer therapy.144