Extracellular lactate weakens antitumor immune responses by suppressing the glycolytic capacity of CD8+ T cells and interfering with IFN-γ signal transduction.153 Conversely, specific lactate concentrations can reshape myeloid cell metabolic programs to promote immunosuppressive microenvironments.154 More importantly, lactate regulates tumor biological behaviors through nonmetabolic pathways. Here, IFNG is linked to neoplasm.