Recent intervention strategies targeting metabolic symbiosis nodes, specifically a low-leucine diet combined with YAP inhibitors, can effectively disrupt the TI-Treg OXPHOS-immunosuppression axis by inhibiting the YAP-Lars2-leucine pathway, suggesting novel approaches to overcome tumor microenvironment-mediated immunosuppression and therapeutic resistance.178. This evidence concerns the gene LARS2 and neoplasm.