Cancer-associated fibroblasts (CAFs) enhance glycolysis reprogramming through circABCC4-mediated PKM2 nuclear translocation to promote oxaliplatin resistance in pancreatic cancer.176 Th17 cell OXPHOS activation can improve antitumor efficacy.177 Stromal stiffness enhances tumor-infiltrating Treg cells (TI-Tregs) OXPHOS via the YAP-Lars2 axis, revealing crosstalk between mechanical signaling and metabolic reprogramming.178. Here, PKM is linked to cancer.