SIRT1 and neoplasm: Tumor-secreted NAMPT induces Naged formation, with SIRT1 serving as a critical transcription factor maintaining the Naged lifecycle through mitochondrial autophagy.409 Respiratory chain-generated mitoROS are now recognized as crucial for NETosis, partly because of mtDNA release.410 These findings underscore the potential for targeted interventions that could modulate neutrophil metabolism to enhance antitumor immunity.