For example, PKM2 mitochondrial translocation can promote cell survival during glucose starvation.254 In colorectal cancer, the long noncoding RNA GLCC1 is significantly upregulated during glucose starvation, supporting cell survival by stabilizing c-Myc.255 Specific molecules, such as mesencephalic astrocyte-derived neurotrophic factor (MANF), can promote breast cancer cell survival under glucose deprivation conditions by regulating mitochondrial autophagy.256. Here, PKM is linked to colorectal cancer.