Through mitochondrial protein deacetylation, SIRT3 reverses the Warburg effect in lung cancer, regulates ROS levels in chronic lymphocytic leukemia, and participates in T-cell differentiation within the TME.290–292 Moreover, SIRT3 enhances ferroptosis by promoting mitochondrial autophagy in glioblastoma and disrupts fatty acid β-oxidation in the CSCs of AML.293,294. The gene discussed is SIRT3; the disease is lung carcinoma.