The mitochondrial LON protein stabilizes the FUNDC1-ULK1 complex, regulating mitochondrial autophagy and participating in cell survival and cancer progression.307 Lipid exchange at MAMs facilitates rapid phospholipid and cholesterol transfer, which is crucial for membrane biosynthesis in highly proliferative cancer cells.308 Even under nutrient deprivation conditions, oncogenic remodeling of MAM-associated protein networks can enhance mitochondrial metabolism. This evidence concerns the gene FUNDC1 and cancer.