TRAF6 and cardiac hypertrophy: In addition, several E3 ubiquitin ligases including MuRF1 [10], Atrogin‐1 [11], Carboxyl terminus of HSP70‐interacting protein (CHIP) [12] and Tumour Necrosis Factor Receptor‐Related Factor 6 (TRAF6) [13], have been reported to participate in the pathological cardiac hypertrophy.