Nonresponse to programmed cell death 1 (PD‐1) blockade is associated with a lack of preexisting IFN‐γ–secreting CD8+ T cells in the tumor microenvironment (TME), which suggests that impaired T‐cell priming or trafficking to tumor tissues might be involved in immune resistance.1, 2, 3. This evidence concerns the gene PDCD1 and neoplasm.