The topmost findings with the strongest negative correlation were: DAPP1, PITPNC1, NR5A2, RP11-466L17.1, MET, TCN1, MYT1L, ITGBL1, ARHGDIB, and AFF1. These changes occurred already in adenomas with low-grade dysplasia suggesting their functional role in early stages of tumorigenesis. The gene discussed is AFF1; the disease is adenoma.