There were three genes with multiple probes, all hypermethylated in FAP: CDX2, GRHL3, and HOXA5. Interestingly, 9% (663/7284) of DMPs were present among common DMPs in all LS tumor groups compared to normal LS mucosa, and 423/663 overlapped with genes (Additional Table 2, 3). Here, GRHL3 is linked to Leigh syndrome.