Of those, 21 were eligible to be compared with expression values and ADHFE1, DAPP1, FBLIM1, GRIA4, HOXA3, KLF17, and ZNF528 revealed statistically significant negative correlation to gene expression suggesting these genes are regulated by DNA methylation and are associated to LS and/or CRC-associated tumorigenesis already at the early stages (Table 4). This evidence concerns the gene ADHFE1 and colorectal carcinoma.