SOX2 and Leigh syndrome: Of those, eight (HOXA3, HOXA5, ATP10A, SOX2, MIR922, ADAMTSL1, KHDRBS2, and LITD1) were hypermethylated in at least one LS tumor group like here in FAP normal, whereas NEDD4L, and FOXP1 were hypermethylated in LS carcinomas and here in LS normal (Additional Table 7).