OR2I1 and adenoma: There were five common DMRs (overlapping with genes) in all tumors, when selecting top 100 DMRs of each tumor group sorted by the smallest FDR value (Additional Table 6, sheet overlappingGenes_common_top100): OR2I1P, OPLAH, NR5A2, MCIDAS, and ARHGDIB. When selecting the common overlapping genes (i.e., gene name was present at least once in all tumors’ DMRs), there were 564, 749, and 634 DMRs in adenomas with low-grade dysplasia, adenomas with high-grade dysplasia, and carcinomas, respectively (Additional Table 6).