Common schizophrenia risk alleles at the KLC1 locus are associated with reduced expression of KLC1 RNA transcripts in the human fetal brain33,34, and knockdown of KLC1 has been found to impair neuronal differentiation35; however, the functional impact of KLC1 missense variants observed in schizophrenia risk are unknown. This evidence concerns the gene KLC1 and schizophrenia.