As examples of differentially phosphorylated proteins seven-days post-TAC, we visualised the differential phosphorylation sites within MYL2 (Myosin Light Chain 2), a sarcomere protein with important roles in cardiac contraction and cardiomyopathies, and CAMK2D (calcium/calmodulin-dependent protein kinase type 2 d), the major CAMK2 isoform expressed in the heart playing key roles in calcium homeostasis in cardiomyocytes and linked to the decompensation from cardiac hypertrophy to heart failure (Fig. 3d)40–42. The gene discussed is MYL2; the disease is cardiac hypertrophy.