Interestingly, in the case of MYL2, the dephosphorylation of Ser15, as we also identified, has been shown to directly contribute to cardiac hypertrophy and dysfunction, impaired calcium sensitivity and contractile force of cardiac muscle, whereas dephosphorylation of the Ser19 inhibits myofilament movement and contraction40,43. The gene discussed is MYL2; the disease is cardiac hypertrophy.