NDUFS1 and cancer: Based on these preliminary findings, we decided to move forward to understand if we could identify a potential redox hub within Ndufs1, which we could then artificially (by incorporating an oxidized Cys mimetic mutation) or physiologically (by increasing mtROS levels) oxidize in A549 cancer cells, to support the concept for a potential redox hub/sensor that could facilitate ETC respirasome formation.