Moreover, characterization of upregulated LRI-depended KEGG pathways with age across all cells in our dataset identified fibrosis-associated KEGG pathways including cellular senescence, pancreatic cancer, and TGFB signaling, further supporting a shift of LRI-depended profibrotic Tgfb1-and Tgfb2-linked alterations (Suppl. The gene discussed is TGFB2; the disease is familial pancreatic carcinoma.