While the number of samples with IHC analysis is too small to draw general conclusions, the available results point toward a slightly different morphology compared to PLAGL1/2-amplified samples with some overlapping embryonal features such as primitive small round blue cells, but at the same time an ependymoma-like appearance with perivascular pseudorosettes in three of four cases as well as GFAP positivity in all four investigated samples, both features that were not or only rarely observed in PLAGL1/2-amplified tumors [11, 25]. This evidence concerns the gene GFAP and ependymoma.