PLAGL1 and embryonal neoplasm: Of note, CNS embryonal tumors with alteration of one of the PLAG family genes should be clearly differentiated from the supratentorial neuroepithelial tumors with PLAGL1 fusion (NET_PLAGL1), which can be epigenetically distinguished from ET, PLAGL and which were described as being more ependymoma-like, and whose clinical behavior was not yet reported [22].