PLAG1 and central nervous system embryonal neoplasm: We describe a rare novel subtype of pediatric CNS embryonal tumor, which is defined by a specific DNA methylation signature and gene fusion of PLAG1 as the 3’ partner and various other genes as 5’ partners, leading to upregulation of PLAG1. The location of the fusion involving the regulatory regions of the 5’ partners as well as the untranslated region (UTR) before exon 4 of PLAG1 suggests promoter hijacking as the mechanism leading to upregulation of PLAG1 expression in those tumors, similar to what is reported for pleomorphic adenomas of the salivary gland [9].