Furthermore, through the application of DNA methylation profiling, multiple new tumor types have been identified and characterized—including our recent publications on supratentorial neuroepithelial tumor with PLAGL1 fusion (NET_PLAGL1), neuroepithelial tumor with PATZ1 fusion (NET-PATZ1), CNS embryonal tumor with PLAGL amplification (ET, PLAGL) [2, 11, 22]—with potential to be added in the next edition of the WHO Classification. The gene discussed is PLAGL1; the disease is central nervous system embryonal neoplasm.