We further confirmed these results by Western blot analysis by analysing MBP and MOBP total protein levels in OLs lysates (Fig. 5c, d and Supplementary Fig. S6c, d), in the hippocampus of 6-month-old 3xTg-AD mice (WT 0.7093 ± 0.05 n = 6 vs. 3xTg-AD 1.032 ± 0.22, n = 5, a.u.)(Supplementary Fig. S6e, f) [13], and in human hippocampus (Control 262.9 ± 67.01 n = 5 vs. AD 381.4 ± 78.43, n = 6, a.u.)(Supplementary Fig. S6g, h). This evidence concerns the gene MOBP and Alzheimer disease.