We thus tested whether reticular stress induced by thapsigargin could enhance antigen expression on the M113 cell line, as we previously demonstrated for MELOE-1 expression.34 We observed that, despite persistent variability in response levels, thapsigargin-induced stress significantly enhanced the recognition of VS17p, SF15-dec1 and SF15-dec2 on M113 cells by their cognate T cells, supporting our hypothesis that translation and processing of these lincRNA-derived peptides is enhanced by stress in melanoma tumors in vivo (Figures 7B,C and S3). The gene discussed is BHLHE41; the disease is melanoma.