Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 expression, and accumulation of CD206‐positive protumor N2 TANs in the tumor microenvironment, thereby promoting tumor growth and metastasis. Here, IL33 is linked to familial pancreatic carcinoma.