We also found that short hairpin RNA (shRNA)‐mediated downregulation of sST2 in mouse Panc02 pancreatic cancer cells suppresses the growth of sST2‐knockdown cells in the pancreas through a reduction in the levels of the neutrophil chemoattractant CXCL3 and the number of tumor‐associated neutrophils (TANs) in the tumor microenvironment, indicating the antitumor and protumor activities of IL‐33 and sST2, respectively [26]. This evidence concerns the gene IL33 and familial pancreatic carcinoma.