Similarly, in the literature, GATA-3 has been reported to be superior to GCDFP-15 and mammaglobin in identifying breast carcinoma in metastatic tumors.16,17 However, GATA-3 has low specificity due to significant positivity in tumors like bladder carcinoma, and this should be kept in mind when attempting to identify the primary tumor in metastatic cases.17 This evidence concerns the gene GATA3 and urinary bladder carcinoma.