NIN and skeletal dysplasia: Based on the function of the NIN gene including chromosome congression during mitosis, centrosome maturation and centrosome architecture and its interaction with CEP110 which has an important role in remodeling microtubules and regulating ciliogenesis, they postulated that NIN is the more likely responsible gene, as genes encoding proteins affecting cilia formation and function have been associated with skeletal dysplasias.5