Semaphorins and their associated proteins, such as CRMPs, are vital for both neural development and cytoskeletal arrangement—processes that rely heavily on functional centrosomes.15 Disruption in Semaphorin signaling could exacerbate cytoskeletal abnormalities, contributing to the skeletal anomalies and intellectual disability observed in the patient.16 Since NIN is essential for maintaining centrosomal architecture, even minor changes in its function could have downstream effects on these developmental processes. Here, NIN is linked to Intellectual disability.