According to recent clinical studies, serial (at least weekly) measurements of C-reactive protein (CRP), white blood cell count (WBC), neutrophil to lymphocyte ratio (NLR) and erythrocyte sedimentation rate (ESR) during treatment guide us to assess response to intravenous (IV) antibiotic therapy in osteomyelitis and are additionally helpful to determine when to switch over from intravenous to oral therapy.13-16. This evidence concerns the gene CRP and osteomyelitis.