Subsequent coculture of pancreatic cancer cells with CTHRC1‐knockdown CAFs‐CM and CTHRC1‐reconstituted‐overexpressing CAFs‐CM demonstrated that CAF‐derived CTHRC1 promotes epithelial‐mesenchymal transition and positively regulates STAT3 signaling pathway activation in cancer cells. Here, CTHRC1 is linked to pancreatic neoplasm.