Finally, to further investigate whether CAF‐derived CTHRC1 activates the STAT3 signaling pathway in pancreatic cancer cells via LIF, we cocultured PDAC cells with conditioned medium from CTHRC1‐overexpressing CAFs (CAFs‐CM) in the presence of the STAT3‐specific inhibitor Stattic. This evidence concerns the gene STAT3 and familial pancreatic carcinoma.