Therefore, to further investigate and verify the role of CTHRC1 in CAFs in regulating LIF and whether CTHRC1 also regulates and activates the STAT3 signaling pathway in pancreatic cancer cells, CAFs‐CM with CTHRC1 knockdown and reconstructed CAFs‐CM with CTHRC1 overexpression were cocultured with Panc‐1. This evidence concerns the gene LIF and familial pancreatic carcinoma.