Using CAFs‐CM with CTHRC1 knockdown or overexpression as the lower chamber medium, the results of the Transwell migration and invasion assays showed that knockdown of CTHRC1 in CAFs significantly inhibited the migration and invasion of pancreatic cancer cells (Figure 3A–C), whereas overexpression of CTHRC1 in CAFs significantly enhanced the migration and invasion of pancreatic cancer cells (Figure 3D,E). The gene discussed is CTHRC1; the disease is familial pancreatic carcinoma.