Finally, to further confirm that CTHRC1 in CAFs activates STAT3 signaling in pancreatic cancer cells via LIF regulation, we cocultured CTHRC1‐overexpressing CAFs‐CM with pancreatic cancer cells in the presence of the LIF inhibitor EC330 and STAT3 inhibitor Stattic. This evidence concerns the gene STAT3 and pancreatic neoplasm.