Two of them, the mitogillin (ribotoxin) Asp f 1 and Asp f 2 of unknown biological function, are markers of genuine sensitization to AF, meaning that the demonstration of Asp f 1 and/or Asp f 2‐specific IgE, with reasonable concordance to extract‐specific IgE, confirms primary sensitization to AF. Here, IGHE is linked to atrial fibrillation.