Several ALS-linked genes encode core autophagy proteins, such as p62/SQSTM1, OPTN, and TBK1, while others influence autophagy function, including C9orf72, FUS, TDP-43, VAPB (Vesicle-Associated Membrane Protein-Associated Protein B), UBQLN2 (Ubiquilin-2), VCP, CHMP2B (Charged Multivesicular Body Protein 2B), ALS2 (Alsin), FIG4 (FIG4 Phosphoinositide 5-Phosphatase), TUBA4A (Tubulin Alpha 4 A), PFN1 (Profilin-1), and DCTN (Dynactin Subunit 1). Here, FIG4 is linked to amyotrophic lateral sclerosis.