Mutations in key proteins, including α-Syn, LRRK2, protein DJ-1 (DJ-1), F-box protein 7 (Fbxo7), and vacuolar protein sorting 35 (VPS35), have been shown to further affect PD pathogenesis through pathways related to Parkin-mediated mitophagy [89]. This evidence concerns the gene LRRK2 and Parkinson disease.