Indeed, we found that the expression of DC maturation markers CD80 and CD86 was significantly upregulated after coculture with irradiated HCT116shARID1A cells (Fig. 4F and G), suggesting that the cancer immunogenicity of ARID1A-deficient cells was strongly triggered by RT to promote DC maturation and the antitumor immune response. The gene discussed is ARID1A; the disease is cancer.