Consistently, proteomic data from Jiang et al. revealed markedly elevated AKR1B1 expression in the tumor tissues of HCC patients with poor prognosis compared with adjacent nontumorous tissues.42 AKR1B1 expression is progressively increased in higher-grade malignant subtypes42 (Supplementary Fig. 38). Here, AKR1B1 is linked to hepatocellular carcinoma.