The results emphasize the dual role of HADHA, an important metabolic enzyme, in GBM progression: on one hand, it directly influences histone acetylation by regulating acetyl-CoA levels; on the other hand, it indirectly controls the proliferation and survival of tumor cells by affecting the activation status of the JAK/STAT3 signaling pathway. The gene discussed is HADHA; the disease is glioblastoma.