METTL5 and cancer: To clarify the carcinogenic and cancer-promoting role of METTL5, we utilized an overexpression lentivirus to elevate the expression of METTL5 in RPMI-8226 and H929 cells, and conducted functional phenotype detection by qPCR and western blot analyses to confirm overexpression (Fig. 2A, B, supplementary Fig. 2A, B).