Further, depletion of SEPHS2 partially decreased the activity of the selenium metabolic pathway triggered by overexpression of METTL5, and promoted DNA damage, activated apoptotic proteins (Fig. 6D, Supplementary Fig. 6G), and promoted apoptosis (Fig. 6E, Supplementary Fig. 6H–J) in METTL5-overexpressing MM cells. Here, METTL5 is linked to Miyoshi myopathy.