In vitro, restoring SEPHS2 expression in stably METTL5-depleted MM cells partially rescued the growth inhibition (Fig. 6F, Supplementary Fig. 7E) and increased apoptosis (Fig. 6G, Supplementary Fig. 7F–H) induced by METTL5 knockdown. The gene discussed is METTL5; the disease is Miyoshi myopathy.