POU5F1 and neoplasm: Accordingly, we also found that VPA, either alone or in combination with CHT, can decrease the protein expression of β-Catenin in tumor tissue samples from mice with CSphC#08 and #147 xenografts (Fig. 5g and Supplementary Fig. 9f) and of oct-4 in tumor tissue samples from mice with CSphC#08 (Fig. 5g).