METTL1 and head and neck squamous cell carcinoma: Furthermore, actinomycin D treatment reveals that METTL1 knockdown accelerates the degradation of TXNDC12 mRNA in HNSCC cells, with both siMETTL1-treated groups showing a more rapid decline in mRNA levels compared with the control siRNA (Fig. 7l and Supplementary Fig. 12c).