Subsequent bioinformatic analysis confirmed a robust positive correlation between METTL1 and TXNDC12 expression across multiple independent HNSCC cohorts, including TCGA HNSCC, GSE30784, GSE41613, GSE136037, GSE2837, GSE25727, GSE40774 and GSE127165 (Fig. 7a and Supplementary Fig. 10). The gene discussed is TXNDC12; the disease is head and neck squamous cell carcinoma.