Subsequent bioinformatic analysis confirmed a robust positive correlation between METTL1 and TXNDC12 expression across multiple independent HNSCC cohorts, including TCGA HNSCC, GSE30784, GSE41613, GSE136037, GSE2837, GSE25727, GSE40774 and GSE127165 (Fig. 7a and Supplementary Fig. 10). This evidence concerns the gene METTL1 and head and neck squamous cell carcinoma.